Population groups, including Aboriginal and Torres Strait Islander peoples, people with disability, and people from culturally and linguistically diverse communities (CALD) experience health inequity and resulting disparities in disease rates. These include higher rates of obesity and associated chronic diseases. This paper brings together three perspectives by researchers in the fields of Indigenous health, disability and CALD health to examine how overweight and obesity impact these populations in Australia and to put forward ways of addressing the problem. The authors urge investment in research co-designed with people from each of these communities and with lived experience of obesity to build valuable knowledge about what preventive actions and interventions will work to reduce obesity rates. They call for evidence-based, tailored obesity prevention programs to address these historical disparities and improve health outcomes among some of Australia's disadvantaged populations.