Neuromorphic engineering is an essential science field which incorporates the basic aspects of issues together such as: physics, mathematics, electronics, etc. The primary block in the Central Nervous System (CNS) is neurons that have functional roles such as: receiving, processing, and transmitting data in the brain. This paper presents Wilson Multiplierless Neuron (WMN) model which is a modified version of the original model. This model uses power-2 based functions, Look-Up Table (LUT) approach and shifters to apply a multiplierless digital realization leads to overhead costs reduction and increases in the final system frequency. The proposed model specifically follows the original neuron model in case of spiking patterns and also dynamical pathways. To validate the proposed model in digital hardware implementation, the FPGA board (Xilinx Virtex II XC2VP30) can be used. Hardware results show the increasing in the system frequency compared with the original model and other similar papers. Numerical results demonstrate that the proposed system speed-up is 210 MHz that is higher than the original one, 85 MHz. Additionally, the overall saving in FPGA resources for the proposed model is 96.86 % that is more than the original model, 95.13 %. From case study viewpoint for CNS consideration, a network consisting of Wilson neurons, synapses, and astrocytes have been considered to test the controlling effects on LTP and LTD processes for investigating the neuronal diseases (medical approaches) such as Epilepsy.