Regenerating the Dental Pulp-Scaffold Materials and Approaches

Diana Gabriela Soares; Vinicius Rosa

doi:10.1016/j.cden.2022.05.010

Regenerating the Dental Pulp-Scaffold Materials and Approaches

Dent Clin North Am. 2022 Oct;66(4):643-657. doi: 10.1016/j.cden.2022.05.010. Epub 2022 Sep 11.

Authors

Diana Gabriela Soares¹, Vinicius Rosa²

Affiliations

¹ Department of Operative Dentistry, Endodontics and Dental Materials, São Paulo University - USP, Bauru School of Dentistry, Dr. Octavio Pinheiro Brizola, 9-75, Bauru, Sao Paulo 17012-901, Brazil. Electronic address: soares.dg@usp.br.
² Faculty of Dentistry, National University of Singapore, 9 Lower Kent Ridge Road, Level 10, Singapore 119085, Singapore. Electronic address: vini@nus.edu.sg.

PMID: 36216451
DOI: 10.1016/j.cden.2022.05.010

Abstract

Novel technologies and platforms have allowed significant breakthroughs in dental pulp tissue engineering. The development of injectable scaffolds that can be combined with stem cells, growth factors, or other bioactive compounds has enabled the regeneration of functional dental pulps able to secrete dentin in preclinical and clinical studies. Similarly, cell-homing technologies and scaffold-free strategies aim to modulate dental pulp self-regeneration mediated by resident stem cells and can evade some of the technical challenges related to cell-based tissue engineering strategies. This article will discuss emerging technologies and platforms for the clinical applications of dental pulp tissue engineering.

Keywords: 3D printing; Bioactive materials; Dentin formation; Growth factors; Odontoblastic differentiation; Tissue engineering.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Cell Differentiation
Dental Pulp*
Dentin
Humans
Regeneration
Tissue Engineering*
Tissue Scaffolds*