Time-course of age-related temporal order memory decline in an object recognition paradigm in mice

Hassina Belblidia; Thomas Freret; Marianne Leger; Pascale Schumann-Bard

doi:10.1016/j.bbr.2022.114151

Time-course of age-related temporal order memory decline in an object recognition paradigm in mice

Behav Brain Res. 2023 Feb 2:437:114151. doi: 10.1016/j.bbr.2022.114151. Epub 2022 Oct 8.

Authors

Hassina Belblidia¹, Thomas Freret², Marianne Leger², Pascale Schumann-Bard³

Affiliations

¹ Normandie Univ, UNICAEN, INSERM, CYCERON, CHU Caen, COMETE UMR 1075, 14000 Caen, France; Université M'hamed Bougara UMBB, Faculté des Sciences, 35000 Boumerdès, Algeria.
² Normandie Univ, UNICAEN, INSERM, CYCERON, CHU Caen, COMETE UMR 1075, 14000 Caen, France.
³ Normandie Univ, UNICAEN, INSERM, CYCERON, CHU Caen, COMETE UMR 1075, 14000 Caen, France. Electronic address: pascale.schumann-bard@unicaen.fr.

PMID: 36216142
DOI: 10.1016/j.bbr.2022.114151

Abstract

Temporal order memory refers to the ability to remember the order of occurrence of items across time. It is a critical feature of episodic memory that is often tested in rodents using spontaneous object recognition paradigms. However, impact of aging over performances of temporal order memory decline is barely known. Herein, we characterized here the eﬀect of normal aging on the temporal order memory performances in NMRI mice between 3 and 19months of age, with an inter-session interval of 24h.We found that temporal order memory was impaired as soon as7 months of age. These results provide strong evidence that temporal order memory is particularly vulnerable to the deleterious eﬀect of normal aging.

Keywords: Memory decline; NMRI mice; Normal aging; Object recognition; Temporal order memory; Y-maze.

MeSH terms

Aging* / psychology
Animals
Memory Disorders* / psychology
Memory, Episodic
Mice
Mice, Inbred Strains
Recognition, Psychology