C(sp3)-H/C(sp3)-H Dehydrogenative Radical Coupling of Glycine Derivatives

Jiayuan Wang; Youwan Ye; Tongzhi Sang; Chenxing Zhou; Xiazhen Bao; Yong Yuan; Congde Huo

doi:10.1021/acs.orglett.2c02951

C(sp³)-H/C(sp³)-H Dehydrogenative Radical Coupling of Glycine Derivatives

Org Lett. 2022 Oct 21;24(41):7577-7582. doi: 10.1021/acs.orglett.2c02951. Epub 2022 Oct 10.

Authors

Jiayuan Wang¹, Youwan Ye¹, Tongzhi Sang¹, Chenxing Zhou¹, Xiazhen Bao¹, Yong Yuan¹, Congde Huo¹

Affiliation

¹ Gansu International Scientific and Technological Cooperation Base of Water-Retention Chemical Functional Materials, Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China.

PMID: 36214657
DOI: 10.1021/acs.orglett.2c02951

Abstract

Here we report a general C(sp³)-H/C(sp³)-H dehydrogenative coupling strategy for the preparation of various natural or unnatural amino acids from readily available glycine derivatives and hydrocarbons through a combination of SET and HAT process.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amines
Amino Acids*
Glycine* / chemistry
Molecular Structure

Substances

Glycine
Amino Acids
Amines