The latest breakthrough on NLRP6 inflammasome

Runzhi Li; Yang Zan; Kaiwen Sui; Shu Zhu

doi:10.1093/pcmedi/pbac022

The latest breakthrough on NLRP6 inflammasome

Precis Clin Med. 2022 Sep 10;5(3):pbac022. doi: 10.1093/pcmedi/pbac022. eCollection 2022 Sep.

Authors

Runzhi Li¹, Yang Zan¹, Kaiwen Sui¹, Shu Zhu^{1

2

3}

Affiliations

¹ Institute of Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Basic Medical Sciences, Division of Life Science and Medicine, University of Science and Technology of China, Hefei 230027, China.
² School of Data Science, University of Science and Technology of China, Hefei 230026, China.
³ Institute of Health and Medicine, Hefei Comprehensive National Science Center, Hefei 230051, China.

Abstract

NLRP6, a Nod-like receptor family member, has been shown to affect intestinal homeostasis and microbial colonization through organizing a huge protein complex called inflammasome. NLRP6 inflammasome promotes the cleavage and secretion of inflammatory cytokines or the cleavage of pore-forming Gasdermin D to initiate the inflammatory cell death called pyroptosis, which plays important roles in responding to pathogen invasion. However, questions about the ligand(s) that trigger NLRP6 inflammasome activation, or the mechanisms that how a ligand triggers NLRP6 inflammasome assembly, are emerging. In this mini-review, we summarize the current understandings of ligand recognition of NLRP6, the role of liquid-liquid phase separation in NLRP6 inflammasome assembly, and potential links with human health and diseases.

Keywords: NLRP6; human disease; inflammasome; phase separation.

Publication types

Review