Case report: Leukemia cutis as the first manifestation of chronic neutrophilic leukemia in a 6-year-old girl

Ya Bin Zhou; Jia Feng Yao; Zi Gang Xu; Rui Hui Wu

doi:10.3389/fped.2022.972224

Case report: Leukemia cutis as the first manifestation of chronic neutrophilic leukemia in a 6-year-old girl

Front Pediatr. 2022 Sep 21:10:972224. doi: 10.3389/fped.2022.972224. eCollection 2022.

Authors

Ya Bin Zhou¹, Jia Feng Yao², Zi Gang Xu¹, Rui Hui Wu²

Affiliations

¹ Department of Dermatology, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.
² Second Hematology Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China.

Abstract

Chronic neutrophilic leukemia (CNL) is a rare BCR-ABL negative myeloproliferative neoplasm that usually affects older adults with a poor prognosis. Leukemia cutis is an extramedullary manifestation of leukemia and may be misdiagnosed by dermatologists. Here, we describe a case of CNL in a 6-year-old Chinese girl with leukemia cutis as the first manifestation. Her skin rashes failed to attract the attention of dermatologists in early stages. The diagnosis was confirmed by peripheral smear, bone marrow studies, genomic analysis and skin biopsy.

Keywords: CSF3R; child; chronic neutrophilic leukemia; leukemia cutis; skin.

Publication types

Case Reports