Objective: To describe the clinical characteristics of pulmonary cryptococcosis(PC)coexisting with lung cancer. Methods: We reported 3 cases of PC coexisting with lung cancer confirmed by pathology in Qingdao Municipal Hospital from January 2017 to December 2021.We reviewed the literature with"pulmonary cryptococcosis" and "lung cancer" as the keywords to search Wanfang database, China HowNet and PubMed database. Results: The patients consisted of 2 males and 1 female. Two patients were diagnosed with nodular type of PC and one with diffuse mixed type of PC. One patient had underlying cardiovascular diseases and the other two had no medical history. The clinical manifestations varied including fever, cough, sputum, and no specific symptoms. All the patients received surgery and postoperative medical therapy, and all 3 patients were pathologically confirmed with adenocarcinoma. A total of 18 cases were retrieved from related literatures. To our knowledge, one of our cases was the first one with diffuse mixed type of PC coexisting with lung cancer. Conclusions: Coexistence of pulmonary cryptococcosis and lung cancer is rare and the clinical symptoms are nonspecific. When PC coexists with lung cancer, it is extremely easy to be misdiagnosed. Therefore, PC should be considered in the differential diagnosis of pulmonary nodules and multiple imaging changes.
目的： 了解肺隐球菌病合并肺癌患者的临床特征。 方法： 回顾分析青岛市市立医院2017年1月至2021年12月经病理确诊的3例肺隐球菌病合并肺癌患者的临床资料，以“肺隐球菌病”联合“肺癌”为检索词搜索万方数据库和中国期刊全文数据库进行检索，以“pulmonary cryptococcosis”联合“lung/pulmonary cancer”为检索词，在PubMed数据库进行文献检索，检索相关文献，进行分析。 结果： 3例患者中，男性2例，女性1例；结节型肺隐球菌病合并肺癌2例，弥漫混合型肺隐球菌病合并肺癌1例；2例既往体健，1例有心血管基础疾病；临床症状表现各不相同，有发热，有咳嗽、咳痰，有无临床症状，体检发现；所有患者均接受外科手术联合术后药物治疗，3例均为腺癌。检索相关文献共有18例报道，弥漫混合型肺隐球菌病合并肺癌目前为第一例报道。 结论： 肺隐球菌病合并肺癌临床少见，临床表现缺乏特异性，两者合并时，易漏诊、误诊，在肺内结节或者多种影像学改变并存的鉴别诊断时，应考虑到隐球菌感染可能。.