Making ends meet: a universal driver of large ribosomal subunit biogenesis

Katherine E Bohnsack; Anthony K Henras; Henrik Nielsen; Markus T Bohnsack

doi:10.1016/j.tibs.2022.09.003

Making ends meet: a universal driver of large ribosomal subunit biogenesis

Trends Biochem Sci. 2023 Mar;48(3):213-215. doi: 10.1016/j.tibs.2022.09.003. Epub 2022 Oct 4.

Authors

Katherine E Bohnsack¹, Anthony K Henras², Henrik Nielsen³, Markus T Bohnsack⁴

Affiliations

¹ Department of Molecular Biology, University Medical Centre Göttingen, Göttingen, Germany. Electronic address: katherine.bohnsack@med.uni-goettingen.de.
² Molecular, Cellular and Developmental Biology Unit, University of Toulouse, Toulouse, France.
³ Department of Cellular and Molecular Medicine, University of Copenhagen, Copenhagen, Denmark.
⁴ Department of Molecular Biology, University Medical Centre Göttingen, Göttingen, Germany; Göttingen Center for Molecular Biosciences, Georg-August University, Göttingen, Germany. Electronic address: markus.bohnsack@med.uni-goettingen.de.

PMID: 36207216
DOI: 10.1016/j.tibs.2022.09.003

Abstract

A common aspect of ribosome assembly, conserved across all domains of life, is the establishment of connections between the 5' and 3' ends of the large subunit (LSU) ribosomal RNA (rRNA) to initiate rRNA domain compaction and subunit assembly. We discuss the diverse mechanisms employed in different organisms to accomplish this important event.

Keywords: RNA folding; RNA helicase; RNA stabilization; circular RNA; ribosome assembly; small nucleolar RNA (snoRNA).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

RNA, Ribosomal*
Ribosomal Proteins / genetics
Ribosome Subunits, Large
Saccharomyces cerevisiae Proteins* / genetics

Substances

RNA, Ribosomal
Saccharomyces cerevisiae Proteins
Ribosomal Proteins