Purpose: To systematically assess the efficacy of psychological intervention for patients with head and neck cancer (HNC) in easing negative emotion and improving quality of life, so as to provide evidence-based reference for clinical psycho-intervention of HNC patients.
Methods: PubMed, Central, Embase, clinicaltrials.gov, ICTRP, Web of science, CBM, CNKI, VIP, and Wan Fang database were searched from inception to 15th, May for randomized controlled trails conducted to assess psychological intervention for HNC patients. The retrieval, screening, quality evaluation, and data extraction were elaborately proceeded by two reviewers independently. Meta analysis was performed using RevMan 5.4 software.
Results: Eighteen RCTs were included with 2 097 participants. Meta analysis showed that compared to control group, psychological intervention group manifested greater decrease in anxiety scores [SMD=-2.33, 95%CI（-2.96，-1.70）, P＜0.000 01] and depression scores [SMD=-2.26, 95%CI（-2.78，-1.74）, P＜0.000 01], and better increase in QOL scores [SMD=6.04, 95%CI（1.53，10.56）, P=0.009] and SQL-90 scores [MD=29.99, 95%CI（-36.22, -23.76），P＜0.000 01].
Conclusions: The anxiety and depression of HNC patients can be effectively relieved through psychological intervention, so that their quality of life and metal health status can be improved. Due to the limitation of quality of included RCT , the result remains to be further validated by more well-designed and better-qualified study.