Aim: To explore the association between preoperative hemoglobin-to-red cell distribution width ratio (HRR), platelet-to-monocyte ratio or monocyte-to-high-density lipoprotein ratio and risk of breast cancer. Materials & methods: The clinical data of 226 patients with breast cancer were retrospectively analyzed and compared with 199 healthy controls by multivariate logistic regression analysis. Results: Multivariate logistic regression analysis revealed that HRR (p < 0.001) and monocyte-to-high-density lipoprotein ratio (p < 0.001) were independent predictors of breast cancer and lower HRR was associated with longer hospitalization, larger red cell distribution width value and lower hemoglobin level (p < 0.05). Conclusion: A significant association was found between HRR and clinical characteristics in breast cancer patients. Therefore, HRR is expected to become a novel and promising predictor of breast cancer.
Keywords: breast cancer; hemoglobin-to-red cell distribution width ratio; monocyte-to-high-density lipoprotein ratio; platelet-to-monocyte ratio.
Breast cancer is a common cancer, accounting for approximately 30% of all new cases of cancer diagnosed in women. It is also one of the main causes of cancer-related death in women. Clinically, breast cancer screening and early diagnosis rely mainly on mammography, ultrasound imaging, etc., but these tests are expensive and complex and are not suitable for early screening of breast cancer. This study found that low hemoglobin-to-red cell distribution width ratio and high monocyte-to-high-density lipoprotein ratio were associated with increased breast cancer risk. Because the determination of hemoglobin-to-red cell distribution width ratio and monocyte-to-high-density lipoprotein ratio is relatively simple, economic and convenient, regular detection of related markers can provide valuable information for early detection of breast cancer.