Recent advances in optical coherence tomography for anterior segment imaging in small animals and their clinical implications

Lisa Beckmann; Zhen Cai; Mathew Margolis; Raymond Fang; Ali Djalilian; Hao F Zhang

doi:10.1016/j.jtos.2022.08.011

Recent advances in optical coherence tomography for anterior segment imaging in small animals and their clinical implications

Ocul Surf. 2022 Oct:26:222-233. doi: 10.1016/j.jtos.2022.08.011. Epub 2022 Oct 3.

Authors

Lisa Beckmann¹, Zhen Cai², Mathew Margolis³, Raymond Fang¹, Ali Djalilian³, Hao F Zhang⁴

Affiliations

¹ Department of Biomedical Engineering, Northwestern University, Evanston IL, USA.
² Department of Biomedical Engineering, Northwestern University, Evanston IL, USA; Currently with Department of Ophthalmology, Tongji Medical College, HuaZhong University of Science and Technology, Wuhan, Hubei, China.
³ Department of Ophthalmology and Visual Science, University of Illinois at Chicago, Chicago IL, USA.
⁴ Department of Biomedical Engineering, Northwestern University, Evanston IL, USA. Electronic address: hfzhang@northwestern.edu.

Abstract

Anterior segment optical coherence tomography (AS-OCT) is a rapidly evolving area of OCT imaging, providing high-resolution and non-invasive volumetric imaging of the anterior segment. This review focuses on recent advances in AS-OCT imaging in small animals, which we categorize into ultrahigh-resolution, spectroscopic, magnetomotive, polarization-sensitive, and angiographic AS-OCTs. We summarize their technical foundations, review their applications to small animal imaging, and briefly discuss their current and future clinical applications.

Keywords: Animal model; Anterior segment; Optical coherence tomography.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anterior Eye Segment* / diagnostic imaging
Tomography, Optical Coherence* / methods

Abstract

Publication types

MeSH terms

Grants and funding