Recent advances and challenges in the bioconversion of acetate to value-added chemicals

Sakuntala Mutyala; Jung Rae Kim

doi:10.1016/j.biortech.2022.128064

Recent advances and challenges in the bioconversion of acetate to value-added chemicals

Bioresour Technol. 2022 Nov:364:128064. doi: 10.1016/j.biortech.2022.128064. Epub 2022 Oct 1.

Authors

Sakuntala Mutyala¹, Jung Rae Kim²

Affiliations

¹ School of Chemical Engineering, Pusan National University, 63 Busandeahak-ro, Geumjeong-Gu, Busan 46241, Republic of Korea.
² School of Chemical Engineering, Pusan National University, 63 Busandeahak-ro, Geumjeong-Gu, Busan 46241, Republic of Korea. Electronic address: j.kim@pusan.ac.kr.

PMID: 36195215
DOI: 10.1016/j.biortech.2022.128064

Abstract

Acetate is a major byproduct of the bioconversion of the greenhouse gas carbon dioxide, pretreatment of lignocellulose biomass, and microbial fermentation. The utilization and valorization of acetate have been emphasized in transforming waste to clean energy and value-added platform chemicals, contributing to the development of a closed carbon loop toward a low-carbon circular bio-economy. Acetate has been used to produce several platform chemicals, including succinate, 3-hydroxypropionate, and itaconic acid, highlighting the potential of acetate to synthesize many biochemicals and biofuels. On the other hand, the yields and titers have not reached the theoretical maximum. Recently, recombinant strain development and pathway regulation have been suggested to overcome this limitation. This review provides insights into the important constraints limiting the yields and titers of the biochemical and metabolic pathways of bacteria capable of metabolizing acetate for acetate bioconversion. The current developments in recombinant strain engineering are also discussed.

Keywords: Acetate metabolism; Acetate valorization; Bioconversion; Circular bioeconomy; Renewable carbon source.