Immunization with messenger RNA vaccines against COVID-19 in adolescents with a history of multisystem inflammatory syndrome: a case series

Arch Argent Pediatr. 2023 Jun 1;121(3):e202202757. doi: 10.5546/aap.2022-02757.eng. Epub 2022 Oct 6.
[Article in English, Spanish]

Abstract

In most cases, children with SARS-CoV-2 have a mild infection. However, very rarely, some children may develop a severe disease called multisystem inflammatory syndrome in children temporally associated with COVID-19 (MIS-C). Given its recent emergence, some aspects of its pathophysiology are still unknown. The possibility of recurrence in case of reinfection or SARS-CoV-2 vaccination are new questions we are facing. Here we report a case series of 4 adolescent patients who developed MIS-C and, months later, received the SARS-CoV-2 vaccine with messenger RNA (mRNA) platforms without disease recurrence or cardiac adverse events.

Los niños cursan mayormente la infección por el virus SARS-CoV-2 en forma leve. Sin embargo, de forma muy infrecuente algunos pueden desarrollar una patología con marcada gravedad denominada síndrome inflamatorio multisistémico en niños relacionado temporalmente con COVID-19 (SIM-C). Dado su reciente surgimiento, aún hay aspectos de su fisiopatología que se desconocen. La posibilidad de recidiva en caso de reinfección o ante la vacunación contra SARS-CoV-2 son nuevos interrogantes a los que nos enfrentamos. Reportamos una serie de casos de 4 pacientes adolescentes que cursaron SIM-C y meses después han sido vacunados contra SARS-CoV-2 con plataformas ARN mensajero (ARNm) sin presentar recurrencia de la enfermedad ni efectos adversos cardiológicos.

Keywords: COVID-19; COVID-19 vaccines; SARS-CoV-2; mRNA vaccines; multisystem inflammatory syndrome in children associatedwith COVID-19.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • COVID-19 Vaccines* / administration & dosage
  • COVID-19* / complications
  • COVID-19* / prevention & control
  • Humans
  • SARS-CoV-2
  • Vaccination
  • mRNA Vaccines / administration & dosage

Substances

  • COVID-19 Vaccines
  • mRNA Vaccines

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related