Mechanisms and inhibitors of ferroptosis in psoriasis

Qiao Zhou; Lijing Yang; Ting Li; Kaiwen Wang; Xiaobo Huang; Jingfen Shi; Yi Wang

doi:10.3389/fmolb.2022.1019447

Mechanisms and inhibitors of ferroptosis in psoriasis

Front Mol Biosci. 2022 Sep 15:9:1019447. doi: 10.3389/fmolb.2022.1019447. eCollection 2022.

Authors

Qiao Zhou^{1

2

3}, Lijing Yang^{2

4}, Ting Li⁵, Kaiwen Wang⁶, Xiaobo Huang⁷, Jingfen Shi⁸, Yi Wang⁷

Affiliations

¹ Health Management Center, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
² Department of Rheumatology and Immunology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
³ Clinical Immunology Translational Medicine Key Laboratory of Sichuan Province, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
⁴ School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
⁵ Department of Rheumatology, Wenjiang District People's Hospital, Chengdu, China.
⁶ School of Medicine, Faculty of Medicine and Health, The University of Leeds, Leeds, United Kingdom.
⁷ Department of Critical Care Medicine, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
⁸ Department of Rheumatology and Immunology, Sichuan Academy of Medical Science and Sichuan Provincial People's Hospital, Wenjiang District People's Hospital, Chengdu, China.

Abstract

Psoriasis is a chronic inflammatory skin disease that features localized or widespread erythema, papules, and scaling. It is common worldwide and may be distributed throughout the whole body. The pathogenesis of psoriasis is quite complex and the result of the interplay of genetic, environmental and immune factors. Ferroptosis is an iron-dependent programmed death that is different from cell senescence, apoptosis, pyroptosis and other forms of cell death. Ferroptosis involves three core metabolites, iron, lipids, and reactive oxygen species (ROS), and it is primarily driven by lipid peroxidation. Ferrostatin-1 (Fer-1) is an effective inhibitor of lipid peroxidation that inhibited the changes related to ferroptosis in erastin-treated keratinocytes and blocked inflammatory responses. Therefore, it has a certain effect on the treatment of psoriatic lesions. Although ferroptosis is closely associated with a variety of human diseases, such as inflammatory diseases, no review has focused on ferroptosis in psoriasis. This mini review primarily focused on the pathogenesis of psoriasis, the mechanisms of ferroptosis, the connection between ferroptosis and psoriasis and ferroptosis inhibitors in psoriasis treatment. We discussed recent research advances and perspectives on the relationship between ferroptosis and psoriasis.

Keywords: ferroptosis; ferrostatin-1; lipid metabolism; psoriasis; treatment.

Publication types

Review