Cerebral venous thrombosis in a young asymptomatic COVID-19 patient

Rafael Dias; Ricardo Soares Dos Reis; Sara Pereira de Sousa; Ana Filipa Rocha; Ana Margarida Ribeiro; Jorge Almeida

doi:10.1097/j.pbj.0000000000000165

Cerebral venous thrombosis in a young asymptomatic COVID-19 patient

Porto Biomed J. 2022 Sep 9;7(4):e165. doi: 10.1097/j.pbj.0000000000000165. eCollection 2022 Jul-Aug.

Authors

Rafael Dias^{1

2

3}, Ricardo Soares Dos Reis^{1

2}, Sara Pereira de Sousa⁴, Ana Filipa Rocha⁵, Ana Margarida Ribeiro⁶, Jorge Almeida^{6

7}

Affiliations

¹ Department of Neurology, Centro Hospitalar Universitário de São João.
² Department of Clinical Neurosciences and Mental Health, Faculty of Medicine of University of Porto.
³ Department of Neurology, Hospital Central do Funchal.
⁴ Department of Immunohemotherapy, Centro Hospitalar Universitário de São João.
⁵ Department of Internal Medicine, Centro Hospitalar do Tâmega e Sousa.
⁶ Department of Internal Medicine, Centro Hospitalar Universitário de São João.
⁷ Department of Medicine, Faculty of Medicine of University of Porto.

Abstract

We report an unusual case of cerebral venous thrombosis (CVT temporally associated with an otherwise asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. While coronavirus disease 2019 (COVID-19) has been associated with thrombotic events at different sites, most published cases report on symptomatic SARS-CoV-2 infection. We are confident this was an otherwise asymptomatic infection as the patient reported no symptoms and molecular and serological testing was consistent with infection more than 3weeks in the past. We believe this is an important report as it adds to the existing literature on thrombotic events in patients with COVID. It may even inform discussion of COVID vaccines and CVT since our patient, as those reported in association with vaccines, also had thrombocytopenia on admission.

Keywords: COVID-19; SARS-CoV-2; asymptomatic; cerebral venous thrombosis.