Study protocol for the OligoMetastatic Esophagogastric Cancer (OMEC) project: A multidisciplinary European consensus project on the definition and treatment for oligometastatic esophagogastric cancer

Tiuri E Kroese; Peter S N van Rossum; Magnus Nilsson; Florian Lordick; Elizabeth C Smyth; Riccardo Rosati; Philippe Nafteux; Domenico D'Ugo; M Asif Chaudry; Wojciech Polkowkski; Franco Roviello; Ines Gockel; Piotr Kolodziejczyk; Karin Haustermans; Matthias Guckenberger; Marianne Nordsmark; Maria A Hawkins; Andres Cervantes; Tania Fleitas; Eric van Cutsem; Markus Moehler; Anna D Wagner; Hanneke W M van Laarhoven; Richard van Hillegersberg; OMEC-working group (Supplementary File 1)

doi:10.1016/j.ejso.2022.09.012

Study protocol for the OligoMetastatic Esophagogastric Cancer (OMEC) project: A multidisciplinary European consensus project on the definition and treatment for oligometastatic esophagogastric cancer

Eur J Surg Oncol. 2023 Jan;49(1):21-28. doi: 10.1016/j.ejso.2022.09.012. Epub 2022 Sep 24.

Authors

Tiuri E Kroese¹, Peter S N van Rossum², Magnus Nilsson³, Florian Lordick⁴, Elizabeth C Smyth⁵, Riccardo Rosati⁶, Philippe Nafteux⁷, Domenico D'Ugo⁸, M Asif Chaudry⁹, Wojciech Polkowkski¹⁰, Franco Roviello¹¹, Ines Gockel¹², Piotr Kolodziejczyk¹³, Karin Haustermans¹⁴, Matthias Guckenberger¹⁵, Marianne Nordsmark¹⁶, Maria A Hawkins¹⁷, Andres Cervantes¹⁸, Tania Fleitas¹⁸, Eric van Cutsem¹⁹, Markus Moehler²⁰, Anna D Wagner²¹, Hanneke W M van Laarhoven²², Richard van Hillegersberg²³; OMEC-working group (Supplementary File 1)

Affiliations

¹ Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
² Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
³ Division of Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden; Department of Upper Abdominal Diseases, Karolinska University Hospital, Stockholm, Sweden.
⁴ Department of Medical Oncology, University Cancer Center Leipzig, Leipzig University Medical Center, Leipzig, Germany.
⁵ Department of Oncology, Cambridge University Hospitals National Health Service Foundation Trust, Hill's Road, Cambridge, UK.
⁶ Department of Gastrointestinal Surgery, San Raffaele Hospital, Milan, Italy.
⁷ Department of Surgery, Katholieke Universiteit Leuven, Leuven, Belgium.
⁸ General Surgery Department, Policlinico Gemelli University Hospital, Rome, Italy.
⁹ Department of Academic Surgery, Royal Marsden NHS Foundation Trust, London, UK.
¹⁰ Department of Surgical Oncology, Medical University of Lublin, Lublin, Poland.
¹¹ Unit of General Surgery and Surgical Oncology, Department of Medicine, Surgery and Neurosciences, University of Siena, Siena, Italy.
¹² Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital of Leipzig, Leipzig, Germany.
¹³ Department of Surgery, Jagiellonian University Medical College, Krakow, Poland.
¹⁴ Department of Radiation Oncology, University Hospitals Leuven, Belgium.
¹⁵ Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
¹⁶ Department of Medical Oncology, Aarhus University, Aarhus, Denmark.
¹⁷ Cancer Institute, University College London, London, UK.
¹⁸ Department of Medical Oncology, Biomedical Research Institute, INCLIVA, University of Valencia, Spain.
¹⁹ Department of Digestive Oncology, University Hospitals Leuven, Leuven, Belgium.
²⁰ Medical Department, University Medical Center, Johannes Gutenberg University Mainz, Mainz, Germany.
²¹ Department of Oncology, Lausanne University Hospital (CHUV), University of Lausanne (UNIL), Lausanne, Switzerland.
²² Department of Medical Oncology, University Medical Centers Amsterdam, University of Amsterdam, Amsterdam, the Netherlands.
²³ Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: R.vanHillegersberg@umcutrecht.nl.

PMID: 36184420
DOI: 10.1016/j.ejso.2022.09.012

Abstract

Background: A uniform definition and treatment for oligometastatic esophagogastric cancer is currently lacking. However, a comprehensive definition of oligometastatic esophagogastric cancer is necessary to initiate studies on local treatment strategies (e.g. metastasectomy or stereotactic radiotherapy) and new systemic therapy agents in this group of patients. For this purpose, the OligoMetastatic Esophagogastric Cancer (OMEC) project was established. The OMEC-project aims to develop a multidisciplinary European consensus statement on the definition, diagnosis, and treatment for oligometastatic esophagogastric cancer and provide a framework for prospective studies to improve outcomes of these patients.

Methods: The OMEC-project consists of five studies, including 1) a systematic review on definitions and outcomes of oligometastatic esophagogastric cancer; 2) real-life clinical scenario discussions in multidisciplinary expert teams to determine the variation in the definition and treatment strategies; 3) Delphi consensus process through a starting meeting, two Delphi questionnaire rounds, and a consensus meeting; 4) publication of a multidisciplinary European consensus statement; and 5) a prospective clinical trial in patients with oligometastatic esophagogastric cancer.

Discussion: The OMEC project aims to establish a multidisciplinary European consensus statement for oligometastatic esophagogastric cancer and aims to initiate a prospective clinical trial to improve outcomes for these patients. Recommendations from OMEC can be used to update the relevant guidelines on treatment for patients with (oligometastatic) esophagogastric cancer.

Keywords: Esophageal cancer; Gastric cancer; Metastasectomy; Oligometastasis; Radiotherapy.

Publication types

Review

MeSH terms

Clinical Trials as Topic
Esophageal Neoplasms* / diagnosis
Esophageal Neoplasms* / therapy
Humans
Prospective Studies
Stomach Neoplasms* / diagnosis
Stomach Neoplasms* / therapy
Systematic Reviews as Topic