Advances in chitosan-based wound dressings: Modifications, fabrications, applications and prospects

Maocheng Ji; Jianyong Li; Yi Wang; Fangyi Li; Jia Man; Jianfeng Li; Chuanwei Zhang; Sixian Peng; Shiqing Wang

doi:10.1016/j.carbpol.2022.120058

Advances in chitosan-based wound dressings: Modifications, fabrications, applications and prospects

Carbohydr Polym. 2022 Dec 1:297:120058. doi: 10.1016/j.carbpol.2022.120058. Epub 2022 Aug 31.

Authors

Maocheng Ji¹, Jianyong Li¹, Yi Wang², Fangyi Li³, Jia Man⁴, Jianfeng Li¹, Chuanwei Zhang⁵, Sixian Peng¹, Shiqing Wang¹

Affiliations

¹ Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, China; National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, China.
² Department of Dermatology, Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, China. Electronic address: wangyi_sdfmu@hotmail.com.
³ Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, China; National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, China. Electronic address: lifangyi@sdu.edu.cn.
⁴ Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, China; National Demonstration Center for Experimental Mechanical Engineering Education, Shandong University, Jinan 250061, China. Electronic address: mj@sdu.edu.cn.
⁵ College of Mechanical and Electrical Engineering, Qingdao University, Qingdao 266071, China.

PMID: 36184154
DOI: 10.1016/j.carbpol.2022.120058

Abstract

In the field of medical research, the development of safe and effective wound dressings is a continuous goal. Chitosan (CS) is highly sought after because of its unique biocompatibility, biodegradability, antibacterial, and healing-promoting properties. The CS molecule has a significant number of active amino and hydroxyl groups; thus, making substitutions and creating derivatives with varied biochemical properties are relatively straightforward processes. This review addresses the range of functions performed by CS and its derivatives in wound care, such as haemostasis, antibacterial, antioxidant, and wound healing. Furthermore, it summarises the various types of CS-based dressings, their performance features and applications. Finally, the future directions of CS-based dressings are proposed.

Keywords: Chitosan; Derivatives; Wound care; Wound dressings; Wound healing.

Publication types

Review

MeSH terms

Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Antioxidants / pharmacology
Bandages
Chitosan* / chemistry
Wound Healing

Substances

Anti-Bacterial Agents
Antioxidants
Chitosan