Sentinel lymph node biopsy in patients with T1a cutaneous malignant melanoma: A multicenter cohort study

Abstract

Background: Sentinel lymph node biopsy is not routinely recommended for T1a cutaneous melanoma due to the overall low risk of positivity. Prognostic factors for positive sentinel lymph node (SLN⁺) in this population are poorly characterized.

Objective: To determine factors associated with SLN⁺ in patients with T1a melanoma.

Methods: Patients with pathologic T1a (<0.80 mm, nonulcerated) cutaneous melanoma from 5 high-volume melanoma centers from 2001 to 2020 who underwent wide local excision with sentinel lymph node biopsy were included in the study. Patient and tumor characteristics associated with SLN⁺ were analyzed by univariate and multivariable logistic regression analyses. Age was dichotomized into ≤42 (25% quartile cutoff) and >42 years.

Results: Of the 965 patients identified, the overall SLN⁺ was 4.4% (N = 43). Factors associated with SLN⁺ were age ≤42 years (7.5% vs 3.7%; odds ratio [OR], 2.14; P = .03), head/neck primary tumor location (9.2% vs 4%; OR, 2.75; P = .04), lymphovascular invasion (21.4% vs 4.2%; OR, 5.64; P = .01), and ≥2 mitoses/mm² (8.2% vs 3.4%; OR, 2.31; P = .03). Patients <42 years with ≥2 mitoses/mm² (N = 38) had a SLN⁺ rate of 18.4%.

Limitations: Retrospective study.

Conclusion: SLN⁺ is low in patients with T1a melanomas, but younger age, lymphovascular invasion, mitogenicity, and head/neck primary site appear to confer a higher risk of SLN⁺.

Keywords: melanoma; prognosis; sentinel lymph node biopsy; surgery; survival; wide local excision.