Hepatic metabolism-related effects of polysaccharides from red kidney bean and small black soybean on type 2 diabetes

Zhouya Bai; Xiaojun Huang; Guangjie Wu; Yujia Zhou; Xingchao Deng; Jingrui Yang; Junyi Yin; Shaoping Nie

doi:10.1016/j.foodchem.2022.134334

Hepatic metabolism-related effects of polysaccharides from red kidney bean and small black soybean on type 2 diabetes

Food Chem. 2023 Mar 1:403:134334. doi: 10.1016/j.foodchem.2022.134334. Epub 2022 Sep 20.

Authors

Zhouya Bai¹, Xiaojun Huang², Guangjie Wu³, Yujia Zhou⁴, Xingchao Deng⁴, Jingrui Yang⁴, Junyi Yin⁴, Shaoping Nie⁴

Affiliations

¹ State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, 235 Nanjing East Road, Nanchang 330047, China; College of Food and Bioengineering, Henan University of Science and Technology, Luoyang, Henan 471023, China.
² State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, 235 Nanjing East Road, Nanchang 330047, China. Electronic address: huangxiaojun0617@163.com.
³ State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, 235 Nanjing East Road, Nanchang 330047, China; School of Life Sciences, Jiangxi Science and Technology Normal University, 605 Fenglin Street, Nanchang, Jiangxi Province 330013, China.
⁴ State Key Laboratory of Food Science and Technology, China-Canada Joint Lab of Food Science and Technology (Nanchang), Nanchang University, 235 Nanjing East Road, Nanchang 330047, China.

PMID: 36182856
DOI: 10.1016/j.foodchem.2022.134334

Abstract

In our previous study, two crude polysaccharides from red kidney bean and small black soybean (RK, SB) have shown the alleviative effect on type 2 diabetic mice. Meanwhile, hepatic dysfunction usually accompanied with type 2 diabetes mellitus (T2DM), and closely related to glucose and lipid homeostasis. Therefore, this time we further investigated the protective effect on hepatic dysfunction of RK and SB. Results found that both crude polysaccharides had the protective effects. In addition, investigation on purified polysaccharides identified that the polysaccharide was the biofunctional component basis in crude RK and SB. Subsequently, further research investigated the regulating mechanism of two pure polysaccharides (RKPH and SBPH) on hepatic metabolism and lipid metabolism. The results showed the improved different metabolites of phosphatidylcholine (PC) and phosphatidylethanolamine (PE) by RKPH and SBPH to affect glycerophospholipid metabolism pathway might be involved in the improvement of the glucose, lipids homeostasis and liver function in T2DM.

Keywords: Hepatic metabolism; Polysaccharides; Red kidney bean polysaccharides; Small black soybean; Type 2 diabetes.

MeSH terms

Animals
Diabetes Mellitus, Experimental* / metabolism
Diabetes Mellitus, Type 2* / drug therapy
Diabetes Mellitus, Type 2* / metabolism
Glucose / metabolism
Glycine max / metabolism
Lipid Metabolism
Liver / metabolism
Mice
Phaseolus* / metabolism
Polysaccharides / pharmacology

Substances

Polysaccharides
Glucose