How does primaquine prevent Plasmodium vivax malarial recurrences?

Miles B Markus

doi:10.1016/j.pt.2022.09.006

How does primaquine prevent Plasmodium vivax malarial recurrences?

Trends Parasitol. 2022 Nov;38(11):924-925. doi: 10.1016/j.pt.2022.09.006. Epub 2022 Sep 27.

Author

Miles B Markus¹

Affiliation

¹ School of Animal, Plant, and Environmental Sciences, Faculty of Science, University of the Witwatersrand, Johannesburg, South Africa; Wits Research Institute for Malaria, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. Electronic address: miles.markus@wits.ac.za.

PMID: 36180306
DOI: 10.1016/j.pt.2022.09.006

Abstract

Flannery et al. and Luiza-Batista et al. recently reported on liver and blood stages of Plasmodium vivax in humanized mice. The biology of P. vivax can be investigated using the mouse models, which will also facilitate drug research. This could lead to better treatment and control of P. vivax malaria.

Keywords: Plasmodium vivax; bone marrow; hypnozoite; primaquine; relapse; spleen.

Publication types

Comment

MeSH terms

Animals
Antimalarials* / pharmacology
Antimalarials* / therapeutic use
Malaria, Vivax* / drug therapy
Malaria, Vivax* / prevention & control
Mice
Plasmodium vivax
Primaquine / pharmacology
Primaquine / therapeutic use
Recurrence

Substances

Antimalarials
Primaquine