Electrochemical DNA sensors for drug determination

G A Evtugyn; A V Porfireva; S V Belyakova

doi:10.1016/j.jpba.2022.115058

Electrochemical DNA sensors for drug determination

J Pharm Biomed Anal. 2022 Nov 30:221:115058. doi: 10.1016/j.jpba.2022.115058. Epub 2022 Sep 16.

Authors

G A Evtugyn¹, A V Porfireva², S V Belyakova²

Affiliations

¹ A.M. Butlerov' Chemistry Institute of Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russian Federation; Analytical Chemistry Department of Chemical Technology Institute of Ural Federal University, 19 Mira Street, Ekaterinburg 620002, Russian Federation. Electronic address: Gennady.Evtugyn@kpfu.ru.
² A.M. Butlerov' Chemistry Institute of Kazan Federal University, 18 Kremlevskaya Street, 420008 Kazan, Russian Federation.

PMID: 36179503
DOI: 10.1016/j.jpba.2022.115058

Abstract

In this review, recent achievements in the development of the DNA biosensors developed for the drug determination have been presented with particular emphasis to the main principles of their assembling and signal measurement approaches. The design of the DNA sensors is considered with characterization of auxiliary components and their necessity for the biosensor operation. Carbon nanomaterials, metals and their complexes as well as electropolymerized polymers are briefly described in the assembly of DNA sensors. The performance of the DNA sensors is summarized within 2017-2022 for various drugs and factors influencing the sensitivity and selectivity of the response are discussed. Special attention is paid to the mechanism of the signal generation and possible drawbacks in the analysis of real samples.

Keywords: Anthracycline determination; Drug determination; Electrochemical DNA sensor; Electropolymerization; Redox active polymer.

Publication types

Review

MeSH terms

Biosensing Techniques*
Carbon
DNA / chemistry
Electrochemical Techniques*
Polymers / chemistry

Substances

Polymers
Carbon
DNA