Role of L-Carnitine supplementation on rate of weight gain and biomarkers of Environmental Enteric Dysfunction in children with severe acute malnutrition: A protocol for a double-blinded randomized controlled trial

PLoS One. 2022 Sep 30;17(9):e0275291. doi: 10.1371/journal.pone.0275291. eCollection 2022.

Abstract

Background: Severe acute malnutrition (SAM) and environmental enteric dysfunction (EED) are highly prevalent among children residing in resource-limited countries like Bangladesh. L-carnitine may play a role in improving the growth and ameliorating the EED among nutritionally vulnerable children.

Objective: To investigate the role of L-carnitine supplementation on the rate of weight gain, duration of hospital stays, and EED biomarkers among children with severe acute malnutrition.

Methods: This study is a double-blinded, placebo-controlled, randomized clinical trial aiming to enroll diarrheal children with SAM between 9-24 months of both sexes attending the nutritional rehabilitation unit (NRU) of Dhaka Hospital of icddr,b. It is an ongoing trial including two arms where one arm receives L-carnitine supplementation, and the other arms receive a placebo for 15 days in addition to the existing standard treatment of SAM. The primary outcome is the rate of weight gain, and the secondary outcomes include duration of hospital stay and EED biomarkers. Outcomes are assessed at baseline and 15 days of post-intervention. We hypothesize that the L- carnitine supplementation for 15 days in children with SAM will improve the rate of weight gain and biomarkers of EED.

Trial registration: ClinicalTrials.gov # NCT05083637. Date of registration: October 19, 2021.

Publication types

  • Clinical Trial Protocol
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bangladesh
  • Biomarkers
  • Carnitine* / therapeutic use
  • Child
  • Dietary Supplements
  • Female
  • Humans
  • Male
  • Randomized Controlled Trials as Topic
  • Severe Acute Malnutrition*
  • Treatment Outcome
  • Weight Gain

Substances

  • Biomarkers
  • Carnitine

Associated data

  • ClinicalTrials.gov/NCT05083637

Grants and funding

#Recipient: Jinat Alam #Award Number: BC#21125966 #Full name of Funder: ‘Rainy Day Grant Fund’ under ‘Young investigator’s award’, primarily financed by the ‘International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) #No. The funders had and will not have a role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.