This review highlights the most recent reports in three powerful and ever-growing fields of borrowing hydrogen, acceptorless dehydrogenative coupling, and base-mediated hydride transfer strategies; which pave the way for generating reactive intermediates via shuttling hydrogen (or hydride) between starting materials without any need for an external hydrogen source to easily construct more complex structures. There is a thorough focus on diversifying the utility of alcohols for C/N-alkylation leading to the synthesis of branched ketones, alcohols, amines, indols, and 6-membered nitrogen-containing heterocycles such as pyridines and pyrimidines, various transformations with the focus on C-C and C-N bond-forming reactions via metal-based catalysis or metal-free approaches in this context to give a global overview in this area.