Rate of broad-spectrum antibiotic overuse in patients receiving outpatient parenteral antibiotic therapy (OPAT)

Jessa R Brenon; Stephanie E Shulder; Sonal S Munsiff; Colleen M Burgoyne; Angela K Nagel; Kelly E Pillinger

doi:10.1017/ash.2021.204

Rate of broad-spectrum antibiotic overuse in patients receiving outpatient parenteral antibiotic therapy (OPAT)

Antimicrob Steward Healthc Epidemiol. 2021 Oct 22;1(1):e36. doi: 10.1017/ash.2021.204. eCollection 2021.

Authors

Jessa R Brenon¹, Stephanie E Shulder², Sonal S Munsiff³, Colleen M Burgoyne³, Angela K Nagel^{4

5}, Kelly E Pillinger²

Affiliations

¹ Johns Hopkins Specialty Infusion Services, Johns Hopkins Home Care Group, Baltimore, Maryland.
² Department of Pharmacy, University of Rochester Medical Center, Rochester, New York.
³ Division of Infectious Diseases, Department of Medicine, University of Rochester Medical Center, Rochester, New York.
⁴ Department of Pharmacy Practice and Administration; Department of Pharmacy, University of Rochester Medical Center, Rochester, New York.
⁵ Wegmans School of Pharmacy, St John Fisher College, Rochester, New York.

Abstract

Broad-spectrum antibiotics with once-daily dosing are often chosen for outpatient parenteral antibiotic therapy (OPAT) due to convenience even when narrower-spectrum antibiotics are appropriate. At our institution, up to 50% of select broad-spectrum OPAT regimens had potential to be narrowed, highlighting the need to re-evaluate regimens for de-escalation prior to discharge.