Dipotassium 1,3,4-thiadiazole-2,5-bis(thiolate) as a new S-donor for direct synthesis of symmetrical disulfides

Mohammad Soleiman-Beigi; Mohammad Alikarami; Homa Kohzadi; Zahra Akbari

doi:10.1038/s41598-022-20642-5

Dipotassium 1,3,4-thiadiazole-2,5-bis(thiolate) as a new S-donor for direct synthesis of symmetrical disulfides

Sci Rep. 2022 Sep 27;12(1):16149. doi: 10.1038/s41598-022-20642-5.

Authors

Mohammad Soleiman-Beigi¹, Mohammad Alikarami², Homa Kohzadi³, Zahra Akbari³

Affiliations

¹ Department of Chemistry, Faculty of Science, Ilam University, P.O. Box 69315516, Ilam, Iran. SoleimanBeigi@yahoo.com.
² Department of Chemistry, Ilam Branch, Islamic Azad University, Ilam, Iran.
³ Department of Chemistry, Faculty of Science, Ilam University, P.O. Box 69315516, Ilam, Iran.

Abstract

In this research, a simple, efficient and novel protocol is eveloped for the direct synthesis of symmetrical disulfides using dipotassium 1,3,4-thiadiazole-2,5-bis(thiolate) as a new, low toxicity, inexpensive, stable solid and free of foul-smelling thiols for synthesize symmetric diaryl/dialkyl disulfides from aryl and alkyl halides in presence of MOF-199 and CuO nanoparticles. Significantly, using this method results in obtaining a variety of symmetrical disulfides in moderate to excellent yields (up to 98%).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Disulfides*
Molecular Structure
Sulfhydryl Compounds*
Thiadiazoles

Substances

Disulfides
Sulfhydryl Compounds
Thiadiazoles
1,3,4-thiadiazole