ERK signaling dynamics: Lights, camera, transduction

Abhineet Ram; John G Albeck

doi:10.1016/j.devcel.2022.09.001

ERK signaling dynamics: Lights, camera, transduction

Dev Cell. 2022 Sep 26;57(18):2151-2152. doi: 10.1016/j.devcel.2022.09.001.

Authors

Abhineet Ram¹, John G Albeck²

Affiliations

¹ Department of Molecular and Cellular Biology, University of California, Davis, CA, USA.
² Department of Molecular and Cellular Biology, University of California, Davis, CA, USA. Electronic address: jgalbeck@ucdavis.edu.

PMID: 36167056
DOI: 10.1016/j.devcel.2022.09.001

Abstract

Three-dimensional mammary epithelial acini are a model for understanding how microenvironment-driven signaling coordinates cell behavior and tissue morphogenesis. In this issue of Developmental Cell, Ender et al. use live-cell imaging to capture dynamic spatiotemporal patterns of ERK activity that instruct cell migration and survival fates in developing acini.

Publication types

Comment

MeSH terms

Acinar Cells
Cell Movement
Epithelial Cells*
Morphogenesis / physiology
Signal Transduction*

Grants and funding

R01 GM115650/GM/NIGMS NIH HHS/United States