Perspectives and challenges to discovering hemoglobin-inducing agents in Sickle Cell Disease

Front Med (Lausanne). 2022 Sep 8:9:1002063. doi: 10.3389/fmed.2022.1002063. eCollection 2022.

¹ Department of Drugs and Medicines, School of Pharmaceutical Sciences, São Paulo State University (UNESP), São Paulo, Brazil.
² Institute of Chemistry, São Paulo State University (UNESP), São Paulo, Brazil.
³ Advanced Research Center in Medicine (CEPAM), School of Medicine, Union of the Colleges of the Great Lakes (UNILAGO), Sao Jose do Rio Preto, SP, Brazil.

No abstract available

Keywords: Cd34 blood cells+; NO/sCG/cGMP pathway; Sickle Cell Disease; clinical trials; epigenetic; fetal hemoglobin; fetal hemoglobin inducers.