Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese

Ke-Yu Zhao; Meng-Lu Yuan; Yun-Na Wu; Hong-Wei Cui; Wen-Yan Han; Jing Wang; Xiu-Lan Su

doi:10.4239/wjd.v13.i8.643

Association of rs1137101 with hypertension and type 2 diabetes mellitus of Mongolian and Han Chinese

World J Diabetes. 2022 Aug 15;13(8):643-653. doi: 10.4239/wjd.v13.i8.643.

Authors

Ke-Yu Zhao¹, Meng-Lu Yuan², Yun-Na Wu³, Hong-Wei Cui⁴, Wen-Yan Han⁵, Jing Wang⁶, Xiu-Lan Su⁷

Affiliations

¹ Clinical Medical Research Center of The Affiliated Hospital, Inner Mongolia Key Laboratory of Medical Cellular Biology, Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China.
² School of Public Health, Inner Mongolia Medical University, Huhhot 010050, Inner Mongolia Autonomous Region, China.
³ Medical Clinical Laboratory, Huhhot First Hospital, Huhhot 010050, Inner Mongolia Autonomous Region, China.
⁴ Department of Scientific Research, Inner Mongolia Autonomous Region Cancer Hospital/The Affiliated People's Hospital of Inner Mongolia Medical University, Huhhot 010050, Inner Mongolia Autonomous Region, China.
⁵ Clinical Medical Laboratory Center, The Second Affiliated Hospital of Inner Mongolia Medical University, Huhhot 010050, Inner Mongolia Autonomous Region, China.
⁶ Graduate School, Inner Mongolia Medical University, Huhhot 010050, Inner Mongolia Autonomous Region, China.
⁷ Clinical Medical Research Center of The Affiliated Hospital, Inner Mongolia Key Laboratory of Medical Cellular Biology, Inner Mongolia Medical University, Hohhot 010050, Inner Mongolia Autonomous Region, China. xlsu@sina.com.

Abstract

Background: Hypertension (HTN) and type 2 diabetes mellitus (T2DM) are often coincident, and each condition is considered a risk factor for the other. Both occur frequently in the Inner Mongolia region of China. The reasons for differences in risk between Han and Mongolian ethnic groups are not known. The LEPR gene and its polymorphism, rs1137101 (Gln223Arg), are both considered risk factors for HTN and T2DM, but any role of rs1137101 in the occurrence of HTN + T2DM remains unclear for Mongolian and Han populations in the Inner Mongolia region.

Aim: To investigate the relationship between rs1137101 and the occurrence of HTN with T2DM in Mongolian and Han populations in Inner Mongolia.

Methods: A total of 2652 subjects of Han and Mongolian ethnic origins were enrolled in the current study, including 908 healthy controls, 1061 HTN patients and 683 HTN patients with T2DM.

Results: The association between the rs1137101 polymorphism and HTN with T2DM was analyzed, and differences between Han and Mongolian individuals assessed. There was a significant correlation between rs1137101 and HTN (co-dominant, dominant, over-dominant and log-additive models) and HTN + T2DM (co-dominant, dominant, over-dominant and log-additive models) after adjustment for sex and age in individuals of Mongolian origin. rs1137101 was significantly associated with HTN (co-dominant, recessive and log-additive models) and HTN + T2DM (co-dominant, dominant, over-dominant and log-additive models) in the Han Chinese population.

Conclusion: Mongolian and Han subjects from Inner Mongolia with HTN who had rs1137101 were protected against the development of T2DM. Allele A has the opposite impact on the occurrence of HTN in Mongolian and Han Chinese populations.

Keywords: Associate study; Han Chinese; Hypertension; Mongolian; Type 2 diabetes mellitus; rs1137101.