Case report: Myocarditis following COVID-19 protein subunit vaccination

Yi-Ming Dong; Xia Liu; Chen-Teng Yang; Qian Qi; Wei-Bo Shi; Ying-Min Li; Min Zuo; Song-Jun Wang; Hai-Tao Bi; Ru-Fei Ma; Guo-Zhong Zhang; Bin Cong

doi:10.3389/fcvm.2022.970045

Case report: Myocarditis following COVID-19 protein subunit vaccination

Front Cardiovasc Med. 2022 Sep 7:9:970045. doi: 10.3389/fcvm.2022.970045. eCollection 2022.

Authors

Yi-Ming Dong¹, Xia Liu¹, Chen-Teng Yang¹, Qian Qi¹, Wei-Bo Shi¹, Ying-Min Li¹, Min Zuo¹, Song-Jun Wang¹, Hai-Tao Bi¹, Ru-Fei Ma¹, Guo-Zhong Zhang¹, Bin Cong¹

Affiliation

¹ Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of Forensic Medical Molecular Identification, Department of Forensic Medicine, Hebei Medical University, Shijiazhuang, China.

Abstract

We report findings in a 34-year-old female patient who presented with fulminant myocarditis 8 days after receiving the first dose of the ZF2001 RBD-subunit vaccine against coronavirus disease 2019 (COVID-19). Autopsy showed severe interstitial myocarditis, including multiple patchy infiltrations of lymphocytes and monocytes in the myocardium of the left and right ventricular walls associated with myocyte degeneration and necrosis. This report highlights the details of clinical presentations and autopsy findings of myocarditis after ZF2001 (RBD-subunit vaccine) vaccination. The correlation between vaccination and death due to myocarditis is discussed.

Keywords: COVID-19; adverse event; autopsy; myocarditis; protein subunit vaccine.

Publication types

Case Reports