The development of hydrogen-oxygen fuel cells with an alkaline electrolyte was highly limited by the sluggish kinetics of the hydrogen oxidation reaction (HOR). Here, with a pyrolysis-reduction route, a new RuNi-based electrocatalyst was prepared, which presents an ultrathin nanowire-like structure. In alkaline media, this catalyst shows an excellent catalytic performance with an exchange current density of 1.10 mA cm-2disk for hydrogen oxidation. The exchange current density and mass activity of this catalyst are much higher than those of its single-metal counterparts and even the commercial Pt/C catalyst containing 20% Pt. Such a remarkable catalytic activity can be explained by the interaction between Ru and Ni; the incorporation of Ni may induce an electronic effect on the optimization of the Ru-Had strength and provide a functional surface that can absorb OH species, thus boosting the catalytic activity. These findings may cast a new light on the exploration of low-cost but high-efficiency catalysts for fuel cells.