Levocarnitine supplementation for asparaginase-induced hepatotoxicity in adult acute lymphoblastic leukemia patients: A multicenter observational study of the campus all group

Marzia Defina; Davide Lazzarotto; Fabio Guolo; Paola Minetto; Nicola Stefano Fracchiolla; Fabio Giglio; Fabio Forghieri; Antonella Vitale; Sabina Chiaretti; Cristina Papayannidis; Matteo Piccini; Antonino Mulè; Monica Bocchia; Matteo Leoncin; Carmela Gurrieri; Lara Aprile; Monia Lunghi; Massimiliano Bonifacio; Crescenza Pasciolla; Marco Cerrano; Monica Fumagalli; Robin Foà; Anna Candoni

doi:10.1016/j.leukres.2022.106963

Levocarnitine supplementation for asparaginase-induced hepatotoxicity in adult acute lymphoblastic leukemia patients: A multicenter observational study of the campus all group

Leuk Res. 2022 Nov:122:106963. doi: 10.1016/j.leukres.2022.106963. Epub 2022 Sep 21.

Authors

Marzia Defina¹, Davide Lazzarotto², Fabio Guolo³, Paola Minetto³, Nicola Stefano Fracchiolla⁴, Fabio Giglio⁵, Fabio Forghieri⁶, Antonella Vitale⁷, Sabina Chiaretti⁷, Cristina Papayannidis⁸, Matteo Piccini⁹, Antonino Mulè¹⁰, Monica Bocchia¹¹, Matteo Leoncin¹², Carmela Gurrieri¹³, Lara Aprile¹⁴, Monia Lunghi¹⁵, Massimiliano Bonifacio¹⁶, Crescenza Pasciolla¹⁷, Marco Cerrano¹⁸, Monica Fumagalli¹⁹, Robin Foà⁷, Anna Candoni²

Affiliations

¹ Hematology Unit, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy. Electronic address: marzia.defina@ao-siena.toscana.it.
² Division of Hematology and Bone Marrow Transplantation, Azienda Sanitaria Universitaria Integrata Friuli Centrale (ASUFC), Udine, Italy.
³ Clinic of Hematology, Department of Internal Medicine (DiMI), University of Genoa, Genoa, Italy.
⁴ Department of Hematology-Oncology and BMT Unit, IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan, Italy.
⁵ Hematology and Bone Marrow Transplantation Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy.
⁶ Department of Medical and Surgical Sciences, Section of Hematology, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria di Modena, Modena, Italy.
⁷ Hematology, Department of Translational and Precision Medicine, "Sapienza" University, Rome, Italy.
⁸ Institute of Hematology "L. and A". Seragnoli, University Hospital S. Orsola-Malpighi, Bologna, Italy.
⁹ Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
¹⁰ Department of Hematology I, Azienda Ospedaliera Ospedali Riuniti Villa Sofia-Cervello, Palermo, Italy.
¹¹ Hematology Unit, Azienda Ospedaliera Universitaria Senese, University of Siena, Siena, Italy.
¹² Hematology Unit, Azienda Ulss3 Serenissima, Ospedale dell'Angelo, Venezia-Mestre, Venice, Italy.
¹³ Dipartimento Strutturale Aziendale Medicina, University of Padova, Padova, Italy.
¹⁴ S.C. Ematologia, Ospedale S.G. Moscati, Taranto, Italy.
¹⁵ Division of Hematology, Department of Translational Medicine, Università del Piemonte Orientale, Novara, Italy.
¹⁶ Department of Medicine, Section of Hematology, Verona University, Verona, Italy.
¹⁷ Hematology Unit, IRCCS Istituto Tumori "Giovanni Paolo II", Bari, Italy.
¹⁸ Department of Molecular Biotechnology and Health Sciences, Division of Hematology, University of Turin, Turin, Italy.
¹⁹ Clinica Ematologica, Ospedale San Gerardo ASST, Monza, Italy.

PMID: 36155352
DOI: 10.1016/j.leukres.2022.106963

No abstract available

Keywords: Acute lymphoblastic leukemia; Asparaginase; Hepatotoxicity; Levocarnitine.

Publication types

Multicenter Study
Observational Study
Letter

MeSH terms

Adult
Antineoplastic Agents* / therapeutic use
Asparaginase / adverse effects
Carnitine / therapeutic use
Chemical and Drug Induced Liver Injury* / etiology
Dietary Supplements / adverse effects
Humans
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / complications
Precursor Cell Lymphoblastic Leukemia-Lymphoma* / drug therapy

Substances

Asparaginase
Carnitine
Antineoplastic Agents