Potential clinical and biochemical markers for the prediction of drug-resistant epilepsy: A literature review

ZhiQiang Li; Wei Cao; HuiLiang Sun; Xin Wang; ShanMin Li; XiangTian Ran; Hong Zhang

doi:10.1016/j.nbd.2022.105872

Potential clinical and biochemical markers for the prediction of drug-resistant epilepsy: A literature review

Neurobiol Dis. 2022 Nov:174:105872. doi: 10.1016/j.nbd.2022.105872. Epub 2022 Sep 22.

Authors

ZhiQiang Li¹, Wei Cao¹, HuiLiang Sun¹, Xin Wang¹, ShanMin Li¹, XiangTian Ran¹, Hong Zhang²

Affiliations

¹ Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China.
² Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, China. Electronic address: hongzhang@cmu.edu.cn.

PMID: 36152944
DOI: 10.1016/j.nbd.2022.105872

Abstract

Drug resistance is a major challenge in the treatment of epilepsy. Drug-resistant epilepsy (DRE) accounts for 30% of all cases of epilepsy and is a matter of great concern because of its uncontrollability and the high burden, mortality rate, and degree of damage. At present, considerable research has focused on the development of predictors to aid in the early identification of DRE in an effort to promote prompt initiation of individualized treatment. While multiple predictors and risk factors have been identified, there are currently no standard predictors that can be used to guide the clinical management of DRE. In this review, we discuss several potential predictors of DRE and related factors that may become predictors in the future and perform evidence rating analysis to identify reliable potential predictors.

Keywords: Biomarker; Drug-resistant epilepsy; Evidence rating; Predictor.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers
Drug Resistance
Drug Resistant Epilepsy* / diagnosis
Drug Resistant Epilepsy* / etiology
Epilepsy* / complications
Epilepsy* / diagnosis
Epilepsy* / drug therapy
Humans
Risk Factors

Substances

Biomarkers