Metastatic and multiply relapsed SDH-deficient GIST and paraganglioma displays clinical response to combined poly ADP-ribose polymerase inhibition and temozolomide

Pediatr Blood Cancer. 2023 Mar;70(3):e30020. doi: 10.1002/pbc.30020. Epub 2022 Sep 24.

Authors

Charu Singh¹, Ranjit S Bindra¹, Peter M Glazer¹, Juan C Vasquez², Farzana Pashankar²

Affiliations

¹ Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut, USA.
² Department of Pediatric Hematology & Oncology, Yale School of Medicine, New Haven, Connecticut, USA.

PMID: 36151992
DOI: 10.1002/pbc.30020

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Diphosphate Ribose
DNA Repair
Gastrointestinal Stromal Tumors*
Humans
Paraganglioma* / drug therapy
Paraganglioma* / genetics
Poly(ADP-ribose) Polymerases / metabolism
Temozolomide / therapeutic use

Substances

Temozolomide
Poly(ADP-ribose) Polymerases
Adenosine Diphosphate Ribose