The link between epigenetics, pain sensitivity and chronic pain

Rocco Giordano; Kristian Kjær-Staal Petersen; Lars Arendt-Nielsen

doi:10.1515/sjpain-2022-0086

The link between epigenetics, pain sensitivity and chronic pain

Scand J Pain. 2022 Sep 26;22(4):664-666. doi: 10.1515/sjpain-2022-0086. Print 2022 Oct 26.

Authors

Rocco Giordano¹, Kristian Kjær-Staal Petersen^{1

2}, Lars Arendt-Nielsen^{1

2

3}

Affiliations

¹ Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health Science and Technology, Faculty of Medicine, Aalborg University, Aalborg, Denmark.
² Center for Mathematical Modeling of Knee Osteoarthritis (MathKOA), Department of Material and Production, Faculty of Engineering and Science, Aalborg University, Aalborg, Denmark.
³ Department of Medical Gastroenterology, Mech-Sense, Aalborg University Hospital, Aalborg, Denmark.

PMID: 36149940
DOI: 10.1515/sjpain-2022-0086

Abstract

Increasing evidence suggests an association between gene expression and clinical pain. Epigenetic modifications are the main modulators of gene expression or protein translation in response to environmental stimuli and pathophysiological conditions. Preclinical and clinical studies indicate that epigenetic modifications could also impact the development of pain, the transition from acute to chronic pain, and the maintenance hereof.

Keywords: epigenetic modifications; epigenetic of pain; microRNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Chronic Pain* / genetics
Epigenesis, Genetic / genetics
Epigenomics
Humans
Pain Threshold