Aberrant resting-state connectivity of auditory, ventral attention/salience and default-mode networks in adults with attention deficit hyperactivity disorder

Rina Blomberg; Carine Signoret; Henrik Danielsson; Irene Perini; Jerker Rönnberg; Andrea Johansson Capusan

doi:10.3389/fnins.2022.972730

Aberrant resting-state connectivity of auditory, ventral attention/salience and default-mode networks in adults with attention deficit hyperactivity disorder

Front Neurosci. 2022 Sep 6:16:972730.. doi: 10.3389/fnins.2022.972730. eCollection 2022.

Authors

Rina Blomberg^{1

2

3}, Carine Signoret^{1

2

3}, Henrik Danielsson^{1

2

3}, Irene Perini^{4

5}, Jerker Rönnberg^{1

2

3

5}, Andrea Johansson Capusan^{4

6}

Affiliations

¹ Department of Behavioral Sciences and Learning, Linköping University, Linköping, Sweden.
² Linnaeus Center HEAD, Linköping University, Linköping, Sweden.
³ Swedish Institute for Disability Research, Linköping University, Linköping, Sweden.
⁴ Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
⁵ Center for Medical Image Science and Visualization, Linköping University, Linköping, Sweden.
⁶ Department of Psychiatry and Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.

Abstract

Background: Numerous resting-state studies on attention deficit hyperactivity disorder (ADHD) have reported aberrant functional connectivity (FC) between the default-mode network (DMN) and the ventral attention/salience network (VA/SN). This finding has commonly been interpreted as an index of poorer DMN regulation associated with symptoms of mind wandering in ADHD literature. However, a competing perspective suggests that dysfunctional organization of the DMN and VA/SN may additionally index increased sensitivity to the external environment. The goal of the current study was to test this latter perspective in relation to auditory distraction by investigating whether ADHD-adults exhibit aberrant FC between DMN, VA/SN, and auditory networks.

Methods: Twelve minutes of resting-state fMRI data was collected from two adult groups: ADHD (n = 17) and controls (n = 17); from which the FC between predefined regions comprising the DMN, VA/SN, and auditory networks were analyzed.

Results: A weaker anticorrelation between the VA/SN and DMN was observed in ADHD. DMN and VA/SN hubs also exhibited aberrant FC with the auditory network in ADHD. Additionally, participants who displayed a stronger anticorrelation between the VA/SN and auditory network at rest, also performed better on a cognitively demanding behavioral task that involved ignoring a distracting auditory stimulus.

Conclusion: Results are consistent with the hypothesis that auditory distraction in ADHD is linked to aberrant interactions between DMN, VA/SN, and auditory systems. Our findings support models that implicate dysfunctional organization of the DMN and VA/SN in the disorder and encourage more research into sensory interactions with these major networks.

Keywords: adults; attention deficit hyperactivity disorder; auditory network; default mode network; functional connectivity; resting state; salience network.