Advances of gold nanoclusters for bioimaging

Cheng Zhang; Xiaobing Gao; Wenrui Chen; Meng He; Yao Yu; Guanbin Gao; Taolei Sun

doi:10.1016/j.isci.2022.105022

Advances of gold nanoclusters for bioimaging

iScience. 2022 Aug 30;25(10):105022. doi: 10.1016/j.isci.2022.105022. eCollection 2022 Oct 21.

Authors

Cheng Zhang¹, Xiaobing Gao², Wenrui Chen¹, Meng He³, Yao Yu³, Guanbin Gao¹, Taolei Sun^{1

3}

Affiliations

¹ State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.
² General Hospital of Central Theater Command, Wuhan 430070, China.
³ School of Chemistry, Chemical Engineering and Life Science, Wuhan University of Technology, 122 Luoshi Road, Wuhan 430070, China.

Abstract

Gold nanoclusters (AuNCs) have become a promising material for bioimaging detection because of their tunable photoluminescence, large Stokes shift, low photobleaching, and good biocompatibility. Last decade, great efforts have been made to develop AuNCs for enhanced imaging contrast and multimodal imaging. Herein, an updated overview of recent advances in AuNCs was present for visible fluorescence (FL) imaging, near-infrared fluorescence (NIR-FL) imaging, two-photon near-infrared fluorescence (TP-NIR-FL) imaging, computed tomography (CT) imaging, positron emission tomography (PET) imaging, magnetic resonance imaging (MRI), and photoacoustic (PA) imaging. The justification of AuNCs applied in bioimaging mentioned above applications was discussed, the performance location of different AuNCs were summarized and highlighted in an unified parameter coordinate system of corresponding bioimaging, and the current challenges, research frontiers, and prospects of AuNCs in bioimaging were discussed. This review will bring new insights into the future development of AuNCs in bio-diagnostic imaging.

Keywords: Medical imaging; Nanomaterials; Optical imaging.

Publication types

Review