Acanthosis nigricans in Insulinoma: Reversible experiments of the nature

Vijay Sheker R Danda; Paidipally Srinivas Rao; Chaitanya Konda; Piyush Lodha

doi:10.1016/j.mjafi.2019.06.002

Acanthosis nigricans in Insulinoma: Reversible experiments of the nature

Med J Armed Forces India. 2022 Sep;78(Suppl 1):S315-S318. doi: 10.1016/j.mjafi.2019.06.002. Epub 2019 Oct 18.

Authors

Vijay Sheker R Danda¹, Paidipally Srinivas Rao¹, Chaitanya Konda¹, Piyush Lodha¹

Affiliation

¹ Department of Endocrinology, Gandhi Medical College/Gandhi Hospital, Musheerabad, Hyderabad, Telangana, 500003, India.

Abstract

Acanthosis Nigricans is considered to be a skin marker of insulin resistance and atherosclerosis. It is rarely reported in cases of insulinoma where there is marked hyperinsulinaemia. We report two cases of insulinoma with acanthosis nigricans which regressed, concomitant with significant weight loss and reduction in blood pressure following surgical resection. This strengthens the hypothesis that hyperinsulinaemia is responsible for Acanthosis nigricans and atherosclerotic risk factors.

Keywords: Acanthosis nigricans; Atherosclerosis; Diabetes; Insulinoma; Regression.

Publication types

Case Reports