Effect of Whole-Body Cryotherapy on Iron Status and Biomarkers of Neuroplasticity in Multiple Sclerosis Women

Bartłomiej Ptaszek; Szymon Podsiadło; Olga Czerwińska-Ledwig; Marcin Maciejczyk; Aneta Teległów

doi:10.3390/healthcare10091681

Effect of Whole-Body Cryotherapy on Iron Status and Biomarkers of Neuroplasticity in Multiple Sclerosis Women

Healthcare (Basel). 2022 Sep 2;10(9):1681. doi: 10.3390/healthcare10091681.

Authors

Bartłomiej Ptaszek¹, Szymon Podsiadło², Olga Czerwińska-Ledwig³, Marcin Maciejczyk⁴, Aneta Teległów³

Affiliations

¹ Institute of Applied Sciences, University of Physical Education in Krakow, 31-571 Krakow, Poland.
² Institute of Clinical Rehabilitation, University of Physical Education in Krakow, 31-571 Krakow, Poland.
³ Institute of Basic Sciences, University of Physical Education in Krakow, 31-571 Krakow, Poland.
⁴ Institute of Biomedical Sciences, University of Physical Education in Krakow, 31-571 Krakow, Poland.

Abstract

The aim of the study was to compare the effect of a series of 20 whole body cryotherapy (WBC) sessions on iron levels and neuroplasticity biomarkers in women with multiple sclerosis (MS) and healthy women. Consent was obtained from the Bioethics Committee at the Regional Medical Chamber in Krakow (87/KBL/OIL/2018; 8 May 2018). The study was registered in the Australian New Zealand Clinical Trials Registry (ACTRN12620001142921; 2 November 2020). The study included 30 people: 15 women with multiple sclerosis (mean age 41.53 ± 6.98 years) and 15 healthy women (mean age 38.47 ± 6.0 years). Both groups attended cryotherapy sessions. Venous blood was collected for analysis before the WBC session and after 20 sessions. In women with MS and healthy women, no significant effect of WBC on changes in the level biomarkers of neuroplasticity was found. There were also no statistically significant differences between the groups of the analyzed indices at the beginning of the study.

Keywords: BDNF; IGF-1; MS; NGF; PDGF; VEGF; iron; neuroplasticity; whole-body cryotherapy.

Grants and funding

The project is financed within the program of the Minister of Science and Higher Education in Poland under the name “Regional Excellence Initiative” in 2019–2022 (project number: 022/RID/2018/19) in the amount of PLN 11,919,908.