Sensational astrocytes: Mechanotransduction in adult brain function

Kevin Hong Chen; Zhaozhu Qiu

doi:10.1016/j.neuron.2022.08.007

Sensational astrocytes: Mechanotransduction in adult brain function

Neuron. 2022 Sep 21;110(18):2891-2893. doi: 10.1016/j.neuron.2022.08.007.

Authors

Kevin Hong Chen¹, Zhaozhu Qiu²

Affiliations

¹ Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² Department of Physiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: zhaozhu@jhmi.edu.

PMID: 36137517
DOI: 10.1016/j.neuron.2022.08.007

Abstract

Sensing the mechanical microenvironment is an essential aspect of all life, yet its mechanism remains poorly understood. In this issue of Neuron, Chi et al. reveal the role of astrocyte mechanosensitive Piezo1 channel in adult neurogenesis and cognitive function.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Astrocytes* / metabolism
Brain / metabolism
Ion Channels* / metabolism
Mechanotransduction, Cellular / physiology
Neurogenesis

Substances

Ion Channels

Abstract

Publication types

MeSH terms

Substances

Grants and funding