Circular RNA in multiple myeloma: A new target for therapeutic intervention

Hefei Ren; Sai Chen; Chang Liu; Hongkun Wu; Zhenhua Wang; Xiaomin Zhang; Jigang Ren; Lin Zhou

doi:10.1016/j.prp.2022.154129

Circular RNA in multiple myeloma: A new target for therapeutic intervention

Pathol Res Pract. 2022 Oct:238:154129. doi: 10.1016/j.prp.2022.154129. Epub 2022 Sep 15.

Authors

Hefei Ren¹, Sai Chen¹, Chang Liu¹, Hongkun Wu¹, Zhenhua Wang¹, Xiaomin Zhang¹, Jigang Ren¹, Lin Zhou²

Affiliations

¹ Department of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai 200003, China.
² Department of Laboratory Medicine, Shanghai Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Shanghai 200003, China. Electronic address: lynnzhou36@126.com.

PMID: 36137401
DOI: 10.1016/j.prp.2022.154129

Abstract

Circular RNAs (circRNAs) are RNA molecules with a stable closed-loop structure that are found in a variety of organisms. CircRNAs are highly stable and conserved, and they play important roles in transcriptional regulation and splicing. Multiple Myeloma (MM) is a malignant proliferative disease for which there are currently no effective and comprehensive treatments. Numerous circRNAs may contribute to the development and progression of MM by acting as oncogenes or regulators. Due to the unique function of circRNAs, they have a high potential for regulating the biological functions (including proliferation and apoptosis) of MM cells, and their expression levels and molecular mechanism are closely related to their diagnostic value, therapeutic sensitivity, and clinical prognosis of MM patients. In this review, we aim to provide a detailed overview of the structure and function of circRNAs and demonstrate the potential therapeutic value and potential mechanism of circRNAs in MM via experiments and clinical trials.

Keywords: Circular RNA; Drug resistance; Multiple myeloma; Therapeutic intervention.

Publication types

Review