Diabetes Mellitus May Exacerbate Liver Injury in Patients with COVID-19: A Single-Center, Observational, Retrospective Study

Mutsuko Minata; Kouji H Harada; Tomoyuki Yamaguchi; Tomoko Fujitani; Hidemitsu Nakagawa

doi:10.1007/s13300-022-01318-9

Diabetes Mellitus May Exacerbate Liver Injury in Patients with COVID-19: A Single-Center, Observational, Retrospective Study

Diabetes Ther. 2022 Dec;13(11-12):1847-1860. doi: 10.1007/s13300-022-01318-9. Epub 2022 Sep 22.

Authors

Mutsuko Minata^{1

2}, Kouji H Harada³, Tomoyuki Yamaguchi^{4

5}, Tomoko Fujitani³, Hidemitsu Nakagawa^{4

5}

Affiliations

¹ Research Institute, Nozaki Tokushukai Hospital, 10-50, 2-chome, Tanigawa, Daito, Osaka, 574-0074, Japan. mmtododon1@gmail.com.
² Nozaki Tokushukai Hospital, 10-50, 2-chome, Tanigawa, Daito, Osaka, 574-0074, Japan. mmtododon1@gmail.com.
³ Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Konoe-cho Yoshida Sakyo-ku, Kyoto City, Kyoto, 606-8501, Japan.
⁴ Research Institute, Nozaki Tokushukai Hospital, 10-50, 2-chome, Tanigawa, Daito, Osaka, 574-0074, Japan.
⁵ Nozaki Tokushukai Hospital, 10-50, 2-chome, Tanigawa, Daito, Osaka, 574-0074, Japan.

Abstract

Introduction: The spread of coronavirus disease 2019 (COVID-19) is having a profound effect on global health. In this study, we investigated early predictors of severe prognosis from the perspective of liver injury and risk factors for severe liver injury in patients with COVID-19.

Methods: We examined prognostic markers and risk factors for severe liver injury by analyzing clinical data measured throughout the course of the illness and the disease severity of 273 patients hospitalized for COVID-19. We assessed liver injury on the basis of aminotransferase concentrations and fibrosis-4 (FIB-4) index on admission, peak aminotransferase concentration during hospitalization, aminotransferase peak-to-average ratio, and albumin and total bilirubin concentrations. Furthermore, we analyzed age, aspartate aminotransferase (AST) concentrations, FIB-4 index on admission, hypertension, diabetes mellitus (DM), dyslipidemia, cerebral infarction, myocardial infarction, and body mass index as mortality risk factors.

Results: We identified advanced age as a risk factor. Among biochemical variables, AST concentration and FIB-4 index on admission were associated with high mortality. AST on admission and peak AST during hospitalization were significantly higher in the non-surviving (n = 45) than the discharged group (n = 228). Multivariable Cox hazards analyses for mortality showed significant hazard ratios for age, peak AST, and FIB-4 index on admission (p = 0.0001 and 0.0108, respectively), but not in a model including AST and FIB-4 index on admission. Furthermore, the AST peak was significantly higher among non-surviving patients with DM than in those without DM.

Conclusions: We found that advanced age, high AST, and FIB-4 index on admission and a higher peak AST during hospitalization are risk factors for poor COVID-19 prognosis. Furthermore, DM was a risk factor for exacerbation of liver injury among non-surviving patients. The AST concentration and FIB-4 index should be assessed periodically throughout hospitalization, especially in patients with high AST values on admission and those with DM.

Keywords: Aminotransferase; COVID-19; Diabetes mellitus; Fibrosis-4; Prognostic marker; SARS-CoV-2.