A triple-diazonium reagent for virus crosslinking and the synthesis of an azo-linked molecular cage

Lijun He; Chenyang Jiang; Zhuoyue Chen; Dejun Ma; Long Yi; Zhen Xi

doi:10.1039/d2ob01583h

A triple-diazonium reagent for virus crosslinking and the synthesis of an azo-linked molecular cage

Org Biomol Chem. 2022 Oct 5;20(38):7577-7581. doi: 10.1039/d2ob01583h.

Authors

Lijun He¹, Chenyang Jiang¹, Zhuoyue Chen¹, Dejun Ma², Long Yi¹, Zhen Xi²

Affiliations

¹ State Key Laboratory of Organic-Inorganic Composites and Beijing Key Lab of Bioprocess, Beijing University of Chemical Technology, Beijing 100029, China. yilong@mail.buct.edu.cn.
² State Key Laboratory of Elemento-Organic Chemistry and Department of Chemical Biology, College of Chemistry, National Pesticide Engineering Research Center, Collaborative Innovation Center of Chemical Science and Engineering, Nankai University, Tianjin 300071, China. madejun@nankai.edu.cn.

PMID: 36131636
DOI: 10.1039/d2ob01583h

Abstract

The first bench-stable triple-diazonium reagent (TDA-1) was rationally designed and synthesized for coupling and crosslinking. The three reactive sites of TDA-1 can react with phenol-containing molecules as well as plant viruses in aqueous buffers efficiently. In addition, a new-type azo-linked cage was constructed by the direct reaction of TDA-1 with a triple-phenol molecule and was characterized by X-ray crystallography.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Crystallography, X-Ray
Diazonium Compounds* / chemistry
Indicators and Reagents
Phenols*

Substances

Diazonium Compounds
Indicators and Reagents
Phenols