Sonogenetics: Recent advances and future directions

Tianyi Liu; Mi Hyun Choi; Jiejun Zhu; Tingting Zhu; Jin Yang; Na Li; Zihao Chen; Quanxiang Xian; Xuandi Hou; Dongmin He; Jinghui Guo; Chunlong Fei; Lei Sun; Zhihai Qiu

doi:10.1016/j.brs.2022.09.002

Sonogenetics: Recent advances and future directions

Brain Stimul. 2022 Sep-Oct;15(5):1308-1317. doi: 10.1016/j.brs.2022.09.002. Epub 2022 Sep 18.

Authors

Tianyi Liu¹, Mi Hyun Choi², Jiejun Zhu¹, Tingting Zhu¹, Jin Yang¹, Na Li³, Zihao Chen³, Quanxiang Xian⁴, Xuandi Hou⁴, Dongmin He¹, Jinghui Guo⁵, Chunlong Fei⁶, Lei Sun⁷, Zhihai Qiu⁸

Affiliations

¹ Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China.
² Department of Bioengineering, Stanford University, CA, USA.
³ Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China; School of Microelectronics, Xidian University, Xi'an, China.
⁴ Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China.
⁵ Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China; Department of Physiology, Faculty of Medicine, Jinan University, Guangzhou, China.
⁶ School of Microelectronics, Xidian University, Xi'an, China.
⁷ Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China. Electronic address: lei.sun@polyu.edu.hk.
⁸ Guangdong Institute of Intelligence Science and Technology, Hengqin, Zhuhai, Guangdong, 519031, China. Electronic address: qiuzhihai@gdiist.cn.

PMID: 36130679
DOI: 10.1016/j.brs.2022.09.002

Abstract

Sonogenetics refers to the use of genetically encoded, ultrasound-responsive mediators for noninvasive and selective control of neural activity. It is a promising tool for studying neural circuits. However, due to its infancy, basic studies and developments are still underway, including gauging key in vivo performance metrics such as spatiotemporal resolution, selectivity, specificity, and safety. In this paper, we summarize recent findings on sonogenetics to highlight technical hurdles that have been cleared, challenges that remain, and future directions for optimization.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Brain* / diagnostic imaging
Ultrasonography