Phenolic Glucosides from the Leaves of Vitex negundo var. cannabifolia

Abstract

Four new phenolic glucosides, cannabifolins G-J (1-4), together with four known ones (5-8), were isolated from the leaves of Vitex negundo var. cannabifolia. Their structures were established by comprehensive analysis of 1D and 2D NMR data and comparison of their spectroscopic and physical data with the literature values. Compound 7 exhibited weak inhibition of nitric oxide production stimulated by lipopolysaccharide in BV-2 microglial cells with IC₅₀ value of 132.8 μM.

Keywords: Verbenaceae; Vitex negundo var. cannabifolia; anti-inflammation; phenolic glucosides.