Pralsetinib and Sequential MET Inhibitors to Overcome MET Amplification Resistance in a Patient With a RET Fusion Driven Lung Cancer - Case Report

Pascal Wang; Lise Matton; Fatima Kebir; Khaldoun Kerrou; Antonin Dubois; Roger Lacave; Jacques Cadranel; Vincent Fallet

doi:10.1016/j.cllc.2022.08.010

Pralsetinib and Sequential MET Inhibitors to Overcome MET Amplification Resistance in a Patient With a RET Fusion Driven Lung Cancer - Case Report

Clin Lung Cancer. 2022 Dec;23(8):e568-e572. doi: 10.1016/j.cllc.2022.08.010. Epub 2022 Aug 20.

Authors

Pascal Wang¹, Lise Matton¹, Fatima Kebir², Khaldoun Kerrou³, Antonin Dubois⁴, Roger Lacave⁵, Jacques Cadranel¹, Vincent Fallet⁶

Affiliations

¹ Department of Pulmonology and Thoracic Oncology, Tenon Hospital, Assistance Publique Hôpitaux de Paris and GRC 4, Theranoscan, Sorbonne Université, Paris, France.
² Pathology Department, Tenon Hospital, AP-HP, Groupe Hospitalier HUEP, Paris, France.
³ Department of Nuclear Medicine, Tenon Hospital, AP-HP, Sorbonne University, Paris, France.
⁴ Department of Pharmacy, Tenon Hospital, AP-HP, Sorbonne University, Paris, France.
⁵ Solid Tumours Genomics Unit, Tenon Hospital, AP-HP, Sorbonne University, Paris, France.
⁶ Department of Pulmonology and Thoracic Oncology, Tenon Hospital, Assistance Publique Hôpitaux de Paris and GRC 4, Theranoscan, Sorbonne Université, Paris, France. Electronic address: vincent.fallet@aphp.fr.

PMID: 36127251
DOI: 10.1016/j.cllc.2022.08.010

No abstract available

Keywords: Combination of tyrosine kinase inhibitors; Non-small cell Lung Carcinoma; Positron-emission tomography; Targeting MET resistance mechanism.

Publication types

Case Reports

MeSH terms

Carcinoma, Non-Small-Cell Lung* / drug therapy
Carcinoma, Non-Small-Cell Lung* / genetics
Humans
Lung Neoplasms* / drug therapy
Lung Neoplasms* / genetics
Protein Kinase Inhibitors / pharmacology
Protein Kinase Inhibitors / therapeutic use
Proto-Oncogene Proteins c-ret / genetics
Pyrazoles / therapeutic use
Pyridines

Substances

pralsetinib
Pyrazoles
Pyridines
Protein Kinase Inhibitors
RET protein, human
Proto-Oncogene Proteins c-ret