Chemical constituents from the stem of Ficus pumila

Wen-Lin Xiao; Wen-Hao Chen; Wei Li; Guang-Ying Chen; Xiao-Ping Song; Chang-Ri Han

doi:10.1080/14786419.2022.2125966

Chemical constituents from the stem of Ficus pumila

Nat Prod Res. 2024 Jan-Feb;38(3):408-414. doi: 10.1080/14786419.2022.2125966. Epub 2022 Sep 20.

Authors

Wen-Lin Xiao^{1

2}, Wen-Hao Chen¹, Wei Li^{1

3}, Guang-Ying Chen¹, Xiao-Ping Song¹, Chang-Ri Han^{1

4}

Affiliations

¹ Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, P. R. China.
² Hainan Center for Disease Control & Prevention, Haikou, P. R. China.
³ Medical College, Hubei University of Arts and Science, XiangYang, HuBei, P. R. China.
⁴ Key Laboratory of Medicinal and Edible Plants Resources of Hainan Province, Hainan Vocational University of Science and Technology, Haikou, P. R. China.

PMID: 36125390
DOI: 10.1080/14786419.2022.2125966

Abstract

A new biphenyl compound: 5-aldehyde-4'-hydroxy-2,2'-dimethoxybiphenyl (1), along with 11 known phenolic compounds (2-12) were isolated from the stem of Ficus pumila Linn. Their structures were established by spectroscopic methods, including MS, UV, IR, 1 D and 2 D NMR. Compounds 4 and 10 showed weakly cytotoxicity against MCF-7, with IC₅₀ values of 32.5 and 37.3 µM, respectively.

Keywords: Ficus pumila; anti-tumor activity; chemical constituents; moraceae.

MeSH terms

Ficus* / chemistry
Magnetic Resonance Spectroscopy