Balancing cell polarity PARts through dephosphorylation

J Cell Biol. 2022 Oct 3;221(10):e202208008. doi: 10.1083/jcb.202208008. Epub 2022 Sep 19.

Abstract

How cells spatially organize their plasma membrane, cytoskeleton, and cytoplasm remains a central question for cell biologists. In this issue of JCB, Calvi et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202201048) identify PP1 phosphatases as key regulators of C. elegans anterior-posterior polarity, by counterbalancing aPKC-mediated phosphorylation of PAR-2.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Caenorhabditis elegans Proteins* / metabolism
  • Caenorhabditis elegans* / cytology
  • Caenorhabditis elegans* / enzymology
  • Cell Membrane
  • Cell Polarity*
  • Cytoplasm
  • Microtubules / metabolism
  • Phosphoprotein Phosphatases* / metabolism
  • Phosphorylation
  • Protein Kinase C* / metabolism

Substances

  • Caenorhabditis elegans Proteins
  • par-2 protein, C elegans
  • PKC-3 protein
  • Protein Kinase C
  • Phosphoprotein Phosphatases