Adipose tissue macrophage in obesity-associated metabolic diseases

Jingfei Yao; Dongmei Wu; Yifu Qiu

doi:10.3389/fimmu.2022.977485

Adipose tissue macrophage in obesity-associated metabolic diseases

Front Immunol. 2022 Sep 2:13:977485. doi: 10.3389/fimmu.2022.977485. eCollection 2022.

Authors

Jingfei Yao¹, Dongmei Wu^{1

2}, Yifu Qiu^{1

2}

Affiliations

¹ Institute of Molecular Medicine, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, College of Future Technology, Peking University, Beijing, China.
² Peking-Tsinghua Center for Life Sciences, Peking University, Beijing, China.

Abstract

Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of ATM on both metabolic homeostatsis and dysfunction. In particular, the macrophage polarization and recruitment as well as the crosstalk between ATM and adipocyte in thermogenesis, obesity, insulin resistance and adipose tissue fibrosis have been reviewed. A better understanding of how ATM regulates adipose tissue remodeling may provide novel therapeutic strategies against obesity and associated metabolic diseases.

Keywords: adaptive thermogenesis; adipokines; adipose tissue macrophage; fibrosis; insulin resistance; obesity.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adipose Tissue / metabolism
Humans
Inflammation* / metabolism
Insulin Resistance*
Macrophages / metabolism
Obesity / metabolism