Pharmacotherapeutic potential of pomegranate in age-related neurological disorders

Mohammad Javad Emami Kazemabad; Sara Asgari Toni; Neda Tizro; Parisa Alsadat Dadkhah; Hanieh Amani; Shima Akhavan Rezayat; Zahra Sheikh; Mohammad Mohammadi; Dorsa Alijanzadeh; Farnoosh Alimohammadi; Mehregan Shahrokhi; Gisou Erabi; Masoud Noroozi; Mohammad Amin Karimi; Sara Honari; Niloofar Deravi

doi:10.3389/fnagi.2022.955735

Pharmacotherapeutic potential of pomegranate in age-related neurological disorders

Front Aging Neurosci. 2022 Sep 1:14:955735. doi: 10.3389/fnagi.2022.955735. eCollection 2022.

Authors

Mohammad Javad Emami Kazemabad¹, Sara Asgari Toni², Neda Tizro³, Parisa Alsadat Dadkhah⁴, Hanieh Amani⁵, Shima Akhavan Rezayat⁶, Zahra Sheikh⁷, Mohammad Mohammadi⁸, Dorsa Alijanzadeh², Farnoosh Alimohammadi⁹, Mehregan Shahrokhi¹⁰, Gisou Erabi¹¹, Masoud Noroozi¹², Mohammad Amin Karimi¹³, Sara Honari⁵, Niloofar Deravi²

Affiliations

¹ Student Research Committee, School of Medicine, Qom University of Medical Sciences, Qom, Iran.
² Student Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
³ School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
⁴ Student Research Committee, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
⁵ Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
⁶ Student Research Committee, Faculty of Medicine, Islamic Azad University of Mashhad, Mashhad, Iran.
⁷ Student Research Committee, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
⁸ Student Research Committee, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
⁹ Student Research Committee, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
¹⁰ School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
¹¹ Student Research Committee, Urmia University of Medical Sciences, Urmia, Iran.
¹² Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Isfahan, Iran.
¹³ School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Abstract

Age-related neurological disorders [AND] include neurodegenerative diseases [NDDs] such as Alzheimer's disease [AD] and Parkinson's disease [PD], which are the most prevalent types of dementia in the elderly. It also includes other illnesses such as migraine and epilepsy. ANDs are multifactorial, but aging is their major risk factor. The most frequent and vital pathological features of AND are oxidative stress, inflammation, and accumulation of misfolded proteins. As AND brain damage is a significant public health burden and its incidence is increasing, much has been done to overcome it. Pomegranate (Punica granatum L.) is one of the polyphenol-rich fruits that is widely mentioned in medical folklore. Pomegranate is commonly used to treat common disorders such as diarrhea, abdominal pain, wound healing, bleeding, dysentery, acidosis, microbial infections, infectious and noninfectious respiratory diseases, and neurological disorders. In the current review article, we aimed to summarize the data on the pharmacotherapeutic potentials of pomegranate in ANDs.

Keywords: Alzheimer's disease (AD); Parkinson's disease (PD); Punica granatum L.; age-related neurological disorders; pomegranate.

Publication types

Review